abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that exposure of mice to low ...

journal_title：Experimental neurology

authors： Hatcher JM,Richardson JR,Guillot TS,McCormack AL,Di Monte DA,Jones DP,Pennell KD,Miller GW

更新日期：2007-04-01 00:00:00

abstract：:Neuropathic pain is common after traumatic injuries to the cauda equina/conus medullaris and brachial plexus. Clinically, this pain is difficult to treat and its mechanisms are not well understood. Lesions to the ventral roots are common in these injuries, but are rarely considered as potential contributors to pain. W...

journal_title：Experimental neurology

authors： Bigbee AJ,Hoang TX,Havton LA

更新日期：2007-03-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in dorsal root ganglia (DRGs) are known to be upregulated and to contribute to the mechanisms of neuropathic pain following peripheral nerve injury. Moreover, transcription factor c-Jun regulates the expressions of both VIP and NPY in cultured DRG neurons. T...

journal_title：Experimental neurology

authors： Son SJ,Lee KM,Jeon SM,Park ES,Park KM,Cho HJ

更新日期：2007-03-01 00:00:00

abstract：:Activity-dependent alteration in synaptic efficacy is referred to as synaptic plasticity and is the believed hallmark of any learning process. Here we employed a recently validated complex maze for spatial training and investigated the impact of repeated and extensive training on basal synaptic transmission of the hip...

journal_title：Experimental neurology

authors： Lange-Asschenfeldt C,Lohmann P,Riepe MW

更新日期：2007-02-01 00:00:00

abstract：:By way of commentary on a recent report that transplanted adult neural progenitor cells can alleviate functional deficits in a rat lesion model of Huntington's disease [Vazey, E.M., Chen, K., Hughes, S.M., Connor, B., 2006. Transplanted adult neural progenitor cells survive, differentiate and reduce motor function imp...

journal_title：Experimental neurology

authors： Dunnett SB,Rosser AE

更新日期：2007-02-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for motoneurons (MNs), and is considered a potential agent for the treatment of amyotrophic lateral sclerosis (ALS) and other MN diseases. The effectiveness of GDNF may depend significantly upon its route of delivery to MNs. In this study w...

journal_title：Experimental neurology

authors： Li W,Brakefield D,Pan Y,Hunter D,Myckatyn TM,Parsadanian A

更新日期：2007-02-01 00:00:00

abstract：:The Fmr1 knockout (KO) mouse is characterized by an increased audiogenic seizure (AGS) susceptibility and is considered a good animal model for epilepsy and seizures in the human fragile-X (FRAX) syndrome. Here, we tested the hypothesis that the reintroduction of the FMR1 gene is able to revert the AGS susceptibility ...

journal_title：Experimental neurology

authors： Musumeci SA,Calabrese G,Bonaccorso CM,D'Antoni S,Brouwer JR,Bakker CE,Elia M,Ferri R,Nelson DL,Oostra BA,Catania MV

更新日期：2007-01-01 00:00:00

abstract：:Antegrade, target-directed axonal regeneration is the explicit goal of nerve repair. However, aberrant and dysfunctional regrowth is commonly observed as well. At the site of surgical nerve coaptation, axonal sprouts encounter fibrotic connective tissue rich in growth-inhibiting chondroitin sulfate proteoglycan that m...

journal_title：Experimental neurology

authors： Graham JB,Neubauer D,Xue QS,Muir D

更新日期：2007-01-01 00:00:00

abstract：:Increased vascular permeability causing vasogenic brain edema is characteristic for many acute neurological diseases such as stroke, brain trauma, and meningitis. Src family kinases, especially c-Src, play an important role in regulating blood-brain barrier permeability in response to VEGF, but also mediate leukocyte ...

journal_title：Experimental neurology

authors： Paul R,Angele B,Popp B,Klein M,Riedel E,Pfister HW,Koedel U

更新日期：2007-01-01 00:00:00

abstract：:Alcohol intake is one of the important lifestyle factors for the risk of insulin resistance and type 2 diabetes. Acetaldehyde, the major ethanol metabolite which is far more reactive than ethanol, has been postulated to participate in alcohol-induced tissue injury although its direct impact on insulin signaling is unc...

journal_title：Experimental neurology

authors： Fang CX,Yang X,Sreejayan N,Ren J

更新日期：2007-01-01 00:00:00

abstract：:Estrogen has been suggested to be pro-epileptic by reducing GABA synthesis, resulting in increased spine density and a decreased threshold for seizures in the hippocampus, which, once they occur, are characterized by a dramatic spine loss in the affected brain areas. As considerable amounts of estradiol are synthesize...

journal_title：Experimental neurology

authors： Zhou L,Lehan N,Wehrenberg U,Disteldorf E,von Lossow R,Mares U,Jarry H,Rune GM

更新日期：2007-01-01 00:00:00

abstract：:We investigated the role of the NO/cGMP system in the vasodilatory response to hypercapnia after cortical spreading depression (CSD) in barbiturate anesthetized rats in vivo. Regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry (LDF). Hypercapnia (arterial pCO2 50-60 mm Hg) increased rCBF by 2.8...

journal_title：Experimental neurology

authors： Scheckenbach KE,Dreier JP,Dirnagl U,Lindauer U

更新日期：2006-12-01 00:00:00

abstract：:Dentate gyrus is usually assumed to be resistant to ischemia. However, the mechanisms underlying this functional plasticity are not fully understood. Herein, we aimed at identifying a neuroprotective mechanism in the dentate gyrus of the adult rat after global ischemia. Cyclic AMP response element (CRE)-binding protei...

journal_title：Experimental neurology

authors： Blanquet PR,Mariani J,Fournier B

更新日期：2006-12-01 00:00:00

abstract：:Neonatal stroke is increasingly recognized in preterm and term infants but the ability to study this condition has been limited by the technical challenges in developing suitable animal models. In the current study we report the use of transient filament middle cerebral artery occlusion for 1.5 h in 10-day-old rat pup...

journal_title：Experimental neurology

authors： Ashwal S,Tone B,Tian HR,Chong S,Obenaus A

更新日期：2006-12-01 00:00:00

abstract：:Contusion of the spinal cord causes an immediate local loss of neurons and disruption of vasculature; additional loss continues thereafter. To explore the possibility of a causal link between delayed endothelial cell (EC) death and secondary neural cell loss, we evaluated neural and endothelial cell survival, and meas...

journal_title：Experimental neurology

authors： Casella GT,Bunge MB,Wood PM

更新日期：2006-11-01 00:00:00

abstract：:We have investigated the expression of TTX-sensitive (TTXs) and TTX-resistant (TTXr) sodium channel subtypes following injury to the inferior alveolar nerve (IAN), in order to determine their potential role in the development of trigeminal neuropathic pain. In seven anaesthetised ferrets, fluorogold (2%) was injected ...

journal_title：Experimental neurology

authors： Davies SL,Loescher AR,Clayton NM,Bountra C,Robinson PP,Boissonade FM

更新日期：2006-11-01 00:00:00

abstract：:Overexpression of nerve growth factor (NGF) using adenoviruses (Adts) after spinal cord injury induces extensive regeneration and sprouting of calcitonin-gene-related peptide immunoreactive (CGRP-IR) fibers, whereas overexpression of cell adhesion molecules (CAMs) has no effect on the normal distribution of these fibe...

journal_title：Experimental neurology

authors： Chaudhry N,de Silva U,Smith GM

更新日期：2006-11-01 00:00:00

abstract：:The retrograde axonal transport mechanism of motor neurons has been exploited to deliver the gene encoding Glial cell line-derived neurotrophic factor (GDNF) into the central nervous system to provide trophic support following injury. A nonviral gene delivery system, consisting of a monoclonal antibody (MC192) that bi...

journal_title：Experimental neurology

authors： Barati S,Hurtado PR,Zhang SH,Tinsley R,Ferguson IA,Rush RA

更新日期：2006-11-01 00:00:00

abstract：:The progressive loss of the nigrostriatal pathway is a distinguishing feature of Parkinson's disease. Because terminal field loss appears to precede cell body loss, we tested whether the mouse mutant Wld(S), which delays axonal degeneration in a variety of disorders, would ameliorate nigrostriatal degeneration followi...

journal_title：Experimental neurology

authors： Hasbani DM,O'Malley KL

更新日期：2006-11-01 00:00:00

abstract：:Mammals adopt a limited number of postures during their day-to-day activities. These stereotyped skeletal configurations are functionally adequate and limit the number of degrees of freedom to be controlled by the central nervous system. The temporal pattern of emergence of these configurations in altricial mammals is...

journal_title：Experimental neurology

authors： Lelard T,Jamon M,Gasc JP,Vidal PP

更新日期：2006-11-01 00:00:00

abstract：:Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was decreased, and the ...

journal_title：Experimental neurology

authors： Borges K,McDermott D,Irier H,Smith Y,Dingledine R

更新日期：2006-10-01 00:00:00

abstract：:Methylmalonic acidemia is an inherited metabolic disorder that leads to brain damage associated to the accumulation of methylmalonic acid (MMA) and impairment of energy metabolism. We demonstrate here that treatment with diazoxide, an agonist of mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)), can prevent death...

journal_title：Experimental neurology

authors： Kowaltowski AJ,Maciel EN,Fornazari M,Castilho RF

更新日期：2006-09-01 00:00:00

abstract：:Amphetamine derivatives are the most commonly abused drugs. These compounds have been known for many years to induce neurotoxicity. However, recent findings have highlighted novel alterations produced by amphetamines in the central nervous system consisting of neuronal inclusions and the involvement of proteins belong...

journal_title：Experimental neurology

authors： Iacovelli L,Fulceri F,De Blasi A,Nicoletti F,Ruggieri S,Fornai F

更新日期：2006-09-01 00:00:00

abstract：:Chronic nerve compression (CNC) injuries induce a robust Schwann cell proliferation in a distinct spatial and temporal pattern, which is accompanied by an increase in the number of small un-myelinated axons in the area of the injury. These findings suggest that this local proliferation of Schwann cells may induce loca...

journal_title：Experimental neurology

authors： Gupta R,Rummler LS,Palispis W,Truong L,Chao T,Rowshan K,Mozaffar T,Steward O

更新日期：2006-08-01 00:00:00

abstract：:Little is known about the morphological effects of alcoholism on the developing adolescent brain and its consequences into adulthood. We studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking...

journal_title：Experimental neurology

authors： Evrard SG,Duhalde-Vega M,Tagliaferro P,Mirochnic S,Caltana LR,Brusco A

更新日期：2006-08-01 00:00:00

abstract：:Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-in...

journal_title：Experimental neurology

authors： dos Santos AA,Pinheiro PC,de Lima DS,Ozias MG,de Oliveira MB,Guimarães NX,Guedes RC

更新日期：2006-08-01 00:00:00

abstract：:The expression of tyrosine hydroxylase (TH) was studied in adult mouse dorsal root ganglia (DRGs) and spinal cord by means of immunohistochemistry and in situ hybridization. TH immunoreactivity and TH mRNA were present in 10-15% of lumbar DRG neurons, in most cases being small/medium-sized. Only very few of these neur...

journal_title：Experimental neurology

authors： Brumovsky P,Villar MJ,Hökfelt T

更新日期：2006-07-01 00:00:00

abstract：:Patients with neuropathic pain frequently experience hypersensitivity to cold stimulation. However, the underlying mechanisms of this enhanced sensitivity to cold are not well understood. After partial nerve injury, the transient receptor potential ion channel TRPV1 increases in the intact small dorsal root ganglion (...

journal_title：Experimental neurology

authors： Katsura H,Obata K,Mizushima T,Yamanaka H,Kobayashi K,Dai Y,Fukuoka T,Tokunaga A,Sakagami M,Noguchi K

更新日期：2006-07-01 00:00:00

abstract：:The neural substrate underlying the aversive effects induced by ethanol abstinence is still unclear. One candidate for such effects is the dorsal periaqueductal gray (dPAG), a core structure of the brain aversion system. The main aim of this study is to examine the role of the dPAG as a possible locus of the aversive ...

journal_title：Experimental neurology

authors： Cabral A,Isoardi N,Salum C,Macedo CE,Nobre MJ,Molina VA,Brandão ML

更新日期：2006-07-01 00:00:00

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...

journal_title：Experimental neurology

authors： Cruz CD,McMahon SB,Cruz F

更新日期：2006-07-01 00:00:00

abstract：:The ability of striatal embryonic grafts to promote functional recovery on complex behavioral tasks depends on various factors, including the amount of striatal-like tissue within the grafts and the duration of post-graft training. However, how the innate paw bias of animals is affected by experience, or influences re...

journal_title：Experimental neurology

authors： Döbrössy MD,Dunnett SB

更新日期：2006-06-01 00:00:00

abstract：:Adult neurogenesis is modulated by growth factors, physical conditions, and other alterations in the physical microenvironment. We studied the effects of focal ischemia on neurogenesis in the subventricular zone (SVZ), olfactory bulb (OB), and hippocampal dentate gyrus (DG) (known to be persistent neurogenic regions) ...

journal_title：Experimental neurology

authors： Koketsu D,Furuichi Y,Maeda M,Matsuoka N,Miyamoto Y,Hisatsune T

更新日期：2006-05-01 00:00:00

abstract：:This study examines cell death and proliferation in the white matter after neonatal stroke. In postnatal day 7 injured rat, there was a marked reduction in myelin basic protein (MBP) immunostaining mainly corresponding to numerous pyknotic immature oligodendrocytes and TUNEL-positive astrocytes in the ipsilateral exte...

journal_title：Experimental neurology

authors： Biran V,Joly LM,Héron A,Vernet A,Véga C,Mariani J,Renolleau S,Charriaut-Marlangue C

更新日期：2006-05-01 00:00:00

abstract：:Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of isolated myelin showed a marked decrease in myelin proteins, phospholipids, and ga...

journal_title：Experimental neurology

authors： Adamo AM,Paez PM,Escobar Cabrera OE,Wolfson M,Franco PG,Pasquini JM,Soto EF

更新日期：2006-04-01 00:00:00

abstract：:Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) are widely expressed in the mature nervous system and are thought to mediate plasticity and repair. We report the generation of transgenic mice that can be induced to express a dominant-negative FGFR (dnFGFR) in select neuronal populations. We show that a mo...

journal_title：Experimental neurology

authors： Eckenstein FP,McGovern T,Kern D,Deignan J

更新日期：2006-04-01 00:00:00

abstract：:We evaluated the effects of allogeneic bone marrow stromal cell treatment of stroke on functional outcome, glial-axonal architecture, and immune reaction. Female Wistar rats were subjected to 2 h of middle cerebral artery occlusion. Rats were injected intravenously with PBS, male allogeneic ACI--or syngeneic Wistar--b...

journal_title：Experimental neurology

authors： Li Y,McIntosh K,Chen J,Zhang C,Gao Q,Borneman J,Raginski K,Mitchell J,Shen L,Zhang J,Lu D,Chopp M

更新日期：2006-04-01 00:00:00

abstract：:In the human embryo, from approximately 6 weeks gestational age (GA), dopaminergic (DA) neurons can be found in the ventral mesencephalon (VM). More specifically, the post-mitotic neurons are located in the ventral part of the tegmentum (VT), whereas no mature DA neurons are found in the neighboring dorsal part. We us...

journal_title：Experimental neurology

authors： Jørgensen JR,Juliusson B,Henriksen KF,Hansen C,Knudsen S,Petersen TN,Blom N,Seiger A,Wahlberg LU

更新日期：2006-04-01 00:00:00

abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can be a highly effective treatment for Parkinson's disease (PD). However, therapeutic efficacy is limited by difficulties in consistently and correctly targeting this nucleus. Increasing evidence suggests that there is abnormal synchronization of beta freq...

journal_title：Experimental neurology

authors： Chen CC,Pogosyan A,Zrinzo LU,Tisch S,Limousin P,Ashkan K,Yousry T,Hariz MI,Brown P

更新日期：2006-03-01 00:00:00

abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...

journal_title：Experimental neurology

authors： Chen KA,Laywell ED,Marshall G,Walton N,Zheng T,Steindler DA

更新日期：2006-03-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the polymerization of wild-type (WT) or mutant alpha-synuclein (AS) into aggregates and fibrils, which are observed as Lewy bodies (LBs) and Lewy neurites (LNs) in PD patients. However, inability to demonstrate aggregation in many cell culture systems is a major drawback fo...

journal_title：Experimental neurology

authors： Pandey N,Schmidt RE,Galvin JE

更新日期：2006-02-01 00:00:00